Sickle Cell Gene Detection (DNA-based)
SKU BLG116
$109.19
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Sickle Cell Gene Detection (DNA-based)
Product Details
Weight: 5.00 lbs
Description:
Sickle Cell Anemia is a common genetic disease that causes long rods in red blood cells, giving them a "sickled" appearance. These cells get stuck in small capillaries of the blood stream leading to oxygen deprivation that causes pain and organ damage. Sickle Cell Anemia is caused by a single point mutation in the hemoglobin gene that results in a faulty protein. In this experiment, your students will investigate the restriction enzyme that discriminates between HbA (normal) and HbS (disease) genes and perform a simulated test on a patient.
Features
• Discover how a single nucleotide mutation can profoundly affect a person’s health
• Explore Mendelian genetics and the molecule methods used to identify sickle cell disease
• Perform agarose gel electrophoresis to separate differently-sized DNA molecules
• Load, run, analyze, and size control samples and samples from a family of three to identify mutations in their hemoglobin genes
Includes:
Instructions, Ready-to-Load QuickStrip™ DNA Samples, UltraSpec-Agarose™, Electrophoresis Buffer (50X), Practice Gel Loading Solution, FlashBlue™ DNA Stain
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